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KMID : 1059519930370040378
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Journal of the Korean Chemical Society
1993 Volume.37 No. 4 p.378 ~ p.389
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e Studies for Release Mechanism of the Steroids in Synthetic Poly(Amino Acid) Matrix
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Kim Ui-Rak
Kang Inn-Kyu
Cho Chong-Su
Lee Myung-Jae
Jeong Bong-Jin
Min Kyung-Sub
Won Mi-Ja
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Abstract
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The release of steroids such as progesterone, testosterone, estrone and estradiol were investigated in two types of block copolymer matrices, which were AB type block copolymer composed of poly(γ-benzyl-L-glutamate)[PBLG] as the A segment and polyoxypropylene[POP] as the B segment and ABA type triblock copolymer composed of the A segment and poly(propylene glycol)[PPG] as the B segment. The release rates of progesterone, estradiol and testosterone through PBLG-POP1 and PBLG-POP2 matrices and those of progesterone, estrone and testosterone through GPG1 of ABA type triblock copolymer were higher in an acidic solution than in a basic one. However, the release rate of estrone through PBLG-POP1 and PBLG-POP2 matrices and that of estradiol through GPG1 of ABA type triblock copolymer were higher in a basic and neutral solutions than in an acidic one. The order of release rate in three different matrices was GPG1 > PBLG-POP1 > PBLG-POP2. The results also showed that the molecular weight of steroids is inversely proportional to the rate of release.
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